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3 Nanoparticles regulate NK cells NK cells in tumors are responsible for destroying tumor cells and preventing tumor development and progression, and activated NK cells can not only produce direct cytotoxic effects through perforin, granzyme release, or death receptor signaling, but also produce cytokines and chemokines to regulate other parts of the immune response (70)
Overall, metformin may inhibit pyroptosis of human granulosa-like tumor cell line cells through the miR-670-3p/NOX2/ROS pathway (Zhou et al., 2023)
Curran MWT, Morhart MJ, Olson JL, et al
a There is significant heterogeneity for FBG (I 2 = 88.5%), Insulin (I 2 = 96.5%), HbA1C (I 2 = 90.5%) and HOMA-IR (I 2 = 98.1)
