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Two controlled studies concluded DSIPs sleep effect was of little clinical significance [11] and not likely to be of major therapeutic benefit. [12] That combination minutes-long half-life, non-monotonic dose-response, delayed and persistent effects, and failed replication is precisely why the field stopped
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However, these early findings are far from conclusive
Individuals who are pregnant, breastfeeding, managing chronic medical conditions, or taking prescription medications should consult a doctor before beginning supplementation
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