Further research has also provided evidence of increased hippocampal BDNF following both acute resistance exercise in insulin-resistant rats (Berbert-Gomes et al., 2024) and increases in basal BDNF concentrations following 8 weeks of progressive ladder-climbing RT (8 climbs, 2 repetitions for each load of 50%, 75%, 90%, and 100% MCL, 3 times per week) in a rodent model of AD (Jafarzadeh et al., 2021)
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Cycling prevents this adaptation by allowing receptors to return to baseline sensitivity during off periods
European journal of clinical nutrition , 72 (1), 105-111