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Most TPE treatments in the United States use the centrifugation method, which separates blood components into layers of red blood cells, plasma, platelets, granulocytes, monocytes, and lymphocytes according to density

Other assays used for cytotoxicity assessment include the cell counting kit-8 assay [166, 196] and the MTS assay [206, 207, 210]

Collective qualitative or quantitative results of these biomarkers may serve to predict potential morbidity and/or mortality of liver disease and failure, leading to appropriate triage of patients into those requiring emergency liver transplantation versus patients who are likely to have good clinical improvement with NAC therapy alone

Immunofluorescence-stained slides were imaged using a CyteFinder II from Rarecyte