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Higher doses (600-1000mcg) are not well studied and may increase costs significantly while potentially causing more side effects
Moreover, SGLT2is have been shown to reduce the incidence of cardiovascular and kidney disease in people with and without diabetes [5, 6], suggesting that these medications should be considered for prevention of cardiovascular and kidney disease, irrespective of HbA 1c levels
Rapid weight loss associated with treatment may also indirectly alter skin barrier function, contributing to dryness or heightened sensitivity
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