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The American Diabetes Association (ADA) guidelines recommend GLP-1 receptor agonists as preferred agents for patients with type 2 diabetes who have established atherosclerotic cardiovascular disease or indicators of high cardiovascular risk, or for those requiring additional glucose-lowering beyond metformin

Some individuals carry genetic patterns that make them naturally more sensitive to GLP-1 effects, meaning they may experience stronger side effects at standard doses

It also makes your cells respond better to the hormone insulin

On average, participants in this study remained on the drug for approximately 13 months before discontinuation