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With the increase of FFA oxidation, PPAR is activated, and the expression of BBD and OCTN2 in oxidative tissue is simulated to facilitate disposal (85)
Jastreboff et al., NEJM, 2023
Losing weight more slowly: Reduces metabolic stress on the body Allows better nutrient intake over time Gives hair follicles time to adapt Maintains better muscle mass Implementation: Work with your healthcare provider to: Use the lowest effective dose of GLP-1 medication Titrate up more gradually if possible Set realistic weekly weight loss goals Focus on sustainable habits rather than maximum speed Strategy 5: Ensure Adequate Caloric Intake Many patients unintentionally eat too few calories due to appetite suppression, worsening stress and deficiency risk
GIP, in contrast, stimulates insulin release in response to glucagon levels
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