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In a Drug Safety Communication published September 16, 2025, the FDA cautions that testosterone products should not be used to treat low testosterone due to aging

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57 The reproducibility of the DTR-QOL was suggested to be acceptable based on an internal consistency for all factors of the questionnaire (Cronbachs alpha 0.81)

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[18] [19] Do not exceed 100 mg total daily dose, as higher amounts may cause nerve damage with prolonged use

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