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The challenge is that awareness has grown much faster than the evidence, so its become difficult for people to separate genuine science from clever marketing. For people frustrated by persistent tendon pain or recurring injuries, that marketing can be particularly persuasive
A.et al (2002)
As fat tissue grows and more NNMT is produced, higher amounts of hormones and pro-inflammatory signals are produced that are responsible for weight gain and other chronic diseases such as type 2 diabetes and cardiovascular disease. NNMT is responsible for converting nicotinamide (NA) into 1-methylnicotinamide (1-MNA), which takes it out of the NAD salvage pathway (see the diagram below)
Morant-Ferrando B, Jimenez-Blasco D, Alonso-Batan P, Agulla J, Lapresa R, Garcia-Rodriguez D, et al
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