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Initially, some patients might need weekly injections, while others might benefit from monthly maintenance dosages
The GSSG-dependent oxidation of roGFP2 by fused PfGrx variants is two to three orders of magnitude faster than the oxidation by unfused PfGrx(SSG) variants and more than seven orders of magnitude faster than the uncatalyzed reaction with GSSG (Table 1)
These results all encourage a conclusion that LASSS treatment (at 1:8000 ratio to HGF) may enhance the c-met binding-affinity of HGF without disturbing HGF-c-Met signaling and that this enhancement occurs through a mechanism that is unrelated to prevention of HGF nitration
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