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Targeted deletion of Sec-tRNA [Ser]Sec ( Trsp ) gene in osteochondroprogenitor cells from embryonic stage caused the depletion of selenoproteins in skeletal systems, causing growth retardation, abnormalities in the epiphyseal growth plate, delayed endochondral ossification, and chondronecrosis, which recapitulated the major pathological features of KBD 73
By using MT-II in conjunction with UV exposure, test subjects will not only experience a change in skin pigmentation due to increased melanin, but will also achieve the desirable shade of tan that results from UV-induced oxidation of melanin to eumelanin
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