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Pen cartridges are temperature-sensitive, and people travelling for more than a couple of days quickly find that a thin insulated wallet does not keep a pen at the right temperature for a long-haul flight or a week in southern Europe in August
Treatment modifications may include temporarily reducing the dose, extending the interval between dose increases, or in some cases, discontinuing semaglutide if side effects remain intolerable despite comprehensive management strategies
Most side effects seem to resolve with slower dose increases and clinical supervision, but the long-term safety picture remains incomplete
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