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It plays a crucial role in maintaining overall health and well-being by protecting cells from oxidative damage caused by free radicals
Together, these interconnected regulatory networks ensure a balanced and controlled inflammatory response, thereby reducing the risk of chronic inflammation and its associated pathologies
Sestrins repress mTORC1 signaling through an AMPK-TSC2-dependent (Budanov and Karin, 2008) or -independent (Peng et al., 2014) manner
However, subsequent investigation revealed its potential therapeutic value in conditions characterized by protein catabolism, muscle wasting, impaired tissue repair, and metabolic dysfunction
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