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The first is metabolic symbiosis between tumor cells: hypoxic cells export lactate and protons via MCT4, while normoxic neighbors import it via MCT1 for oxidative phosphorylation, thereby optimizing intra-tumoral resource utilization [45]
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Given that dietary factors do not significantly influence UA supplementation, the associated safety concerns are minimized
Consequently, the riskbenefit evaluation of these peptides should include a comprehensive assessment of individual cancer risk
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