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This is a mechanism-based concern, not a confirmed risk, but it would warrant HPA axis biomarkers (morning cortisol, ACTH) in a pediatric trial protocol
Solinas G, Becattini B
37 Interpretation of these findings is constrained by potential underreporting of biliary outcomes and reliance on aggregate trial-level data rather than individual patient data
About long-term planning: "What happens if I stop taking it ?" "How will we monitor my progress and adjust treatment?" "At what point would we consider switching to a different medication ?" Long-term questions impress doctors because they show you understand this is not a quick fix
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