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Discard if color shifts from pale blue to brown or green, which indicates copper speciation change
Mechanistically, it activates Nrf2 and its nuclear translocation, thereby enhancing the expression of downstream antioxidant genes to relieve oxidative stress
First, the benzyl alcohol begins to degrade
Collectively, these charge-, size-, and injury-dependent mechanisms provide a robust mechanistic framework for the enhanced renal availability and therapeutic superiority of PTX-CSNPs observed in this study
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