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Next, mitochondrial citrate is transported across the inner mitochondrial membrane via a citrate carrier (CIC or SLC25A1) to support fatty acid synthesis for tumor progression in hypoxia 73 (Fig

Metabolomic analysis further demonstrated clearance of lipotoxic intermediates, decreased pro-inflammatory lipids, reduced collagen-derived metabolites, and elevated anti-inflammatory 15-HETE, confirming metabolic restoration at multiple regulatory levels

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Retatrutide is a next-generation triple agonist (GLP-1, GIP, and GCGR) widely examined in laboratory studies focused on energy balance, metabolic regulation, and multi-pathway peptide signalling