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reported that MTX caused weight loss due to malabsorption and enterocolitis in rats (Reference Fox, Kripke and De Paula37,Reference Jahovic, Cevik and Sehirli38)
& Sharp, P
Start at 0.25 mg (5 units) once weekly, step up every 4 weeks (0.5, 1.0, 1.7), then hold 2.4 mg (48 units) from week 17 , subcutaneously, same day each week
In man and rat as well as many mammalian species, AFB 1 -8,9-epoxide is efficiently conjugated with reduced glutathione
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