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Multiple other causes should be considered including peripheral vascular disease, neuropathy, medication effects from other drugs (particularly diuretics, beta-agonists, and statins), hypothyroidism, pregnancy, and musculoskeletal conditions
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Research shows that semaglutide and similar compounds do not have direct pharmacokinetic interactions with warfarin, apixaban, or other blood thinners, but clinical supervision remains essential to monitor individual response patterns and optimize outcomes