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The prolonged half-life of GLP-1 analogs is achieved through several mechanisms, such as delayed absorption from the subcutaneous injection site, albumin binding, which shields the molecule from enzymatic degradation by DPP-4, and reduced renal clearance
A patient who loses 40 pounds but half of it's muscle will look and feel very different from a patient who loses 40 pounds and 85 percent of it's fat
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