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After a median follow-up of 2 years, the incidence of new or worsening nephropathy in the semaglutide group was lower than that in the placebo group [HR 0.64 (95% CI: 0.460.88, p=0.05)]

The co-crystal structure of Compound 71 bound to PDE10A revealed that, in addition to existing interactions, an extra halogen bond formed between the chlorine atom of Compound 71 and Y524, contributing to enhanced inhibitory activity (Figure 18B)

Exosomal LncRNA LINC00659 transferred from cancer-associated fibroblasts promotes colorectal cancer cell progression via miR-342-3p/ANXA2 axis