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Accordingly, these outcomes represent longitudinal real-world observations rather than standardized timepoint efficacy estimates

Decomposition: persistence 15% (1.82), lifestyle 9% (1.08), early 6.5% (0.78), care 3.9% (0.47), titration 2.1% (0.25). From Individual Attribution to Population Effectiveness: Regulatory and System-Level Simulations Regulatory approval establishes that a medicine is effective under controlled conditions, but post-approval decision-making increasingly focuses on whether that effectiveness is realized in real-world use

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Unimolecular multi-receptor agonist A single molecular entity engineered to activate two or more distinct receptors