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By activating GLP-1 receptors, tirzepatide enhances glucose-dependent insulin secretion from pancreatic beta cells, suppresses inappropriate glucagon release, slows gastric emptying, and reduces appetite through central nervous system pathways
Under glucose-deprived conditions, glutamine-derived fumarate, malate, and citrate are significantly increased 45
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Glucagon responses of isolated cells to glucose, insulin, somatostatin, and leptin
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