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In a 4-year CV outcomes trial (Trial 7), 4,825 patients were randomized to RYBELSUS for a median follow-up of 49.6 months and 4,825 patients were randomized to placebo for a median follow-up of 49.4 months [see Clinical Studies (14.4)]
Rare but serious adverse effects including pancreatitis, gallbladder disease, or severe allergic reactions may require immediate cessation
The three-pronged approach is an interesting one, covering GLP-1 production, fat burning, and sleep quality
Examples of the relative abundance of specific proteins at baseline and week 68 in STEP 1 and STEP 2 are shown in Extended Data Fig
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