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Persistent AGERAGE activation can enhance cytokine production and ROS accumulation, creating a microenvironment that favors TGF-1 activation, extracellular matrix deposition, and fibrotic remodeling (145)
Mitochondrial oxidative stress and respiratory dysfunctions in cancer cells may, therefore, lead to the activation of apoptotic signals by the release of apoptosis-inducing factors and proteins and subsequent activation of the caspases [17], [18], [19]
U., Chen, X
Patchy hair loss requires prompt dermatological evaluation and potentially immunosuppressive treatment
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