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This is one of the core pathological mechanisms underlying obesity, diabetes, and other metabolic diseases
The ratio of Firmicutes to Bacteroidetes is a commonly-studied change with an increase often linked to HFD consumption/obesity in mice 43,44 and humans 45,46 (for review, see John and Mullin, 2016 47 )
However, weight changes vary based on diet, exercise, and overall health
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