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doi: 10.1007/s11739-020-02470-5 32 DuttaroyAK
The conventional and rapid antidepressants not only rely on the expression of BDNF and its downstream signaling for their efficacy, but they also directly interact with the transmembrane structural domain of the TrkB dimer, leading to the stabilization of a multiprotein complex conformation that facilitates TrkB binding to BDNF
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