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The efficacy and safety of the new GLP-1 medicines continues to garner interest and will be discussed #ADA2024 Here is an updated safety-focused summary of the field and where it might be headed @DiabetesCareADA #T2D #obesity pic.twitter.com/rtEQYtHQG0 Daniel J Drucker (@DanielJDrucker) June 6, 2024 Investigational GLP-1 medicines in the clinic Late-stage investigational GLP-1 medicines for type 2 diabetes and obesity include new molecules like retatrutide and orforglipron, showing potential differentiation from semaglutide and tirzepatide through better tolerability, greater weight loss, Hb A 1c reduction, and targeted outcomes
These have mostly been observed in rodents, which are known to have more C-cells than humansbut it also has been reported in humans with liraglutide
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Accessed 11 February 2021 Joubert M, Benhamou P-Y, Schaepelynck P et al (2019) Remote monitoring of diabetes: a cloud-connected digital system for individuals with diabetes and their health care providers
