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This drug class has been around for two decades, and the latest approved iterations, semaglutide and tirzepatide, are substantially more effective at helping people lose weight and control their blood sugar than diet and exercise alone
It is the leading cause of nephropathy and end-stage kidney disease, neuropathy, retinopathy and adult-onset blindness, non-traumatic amputation, and contributes greatly to heart disease and cardiovascular morbidity and mortality ( This meta-analysis showed that when initiated at the prediabetic stage, interventions with medications, specifically SGLT-2 inhibitors and GLP-1 receptor agonists, show promising evidence in delaying the progression of prediabetes into diabetes
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Despite these advances, the fundamental understanding of polymerelectrolyte interactions, particularly their influence on the electrical double layer and ion transport mechanisms, remains limited
