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Important safety questions include product purity, dose accuracy, drug interactions, liver and kidney considerations, blood sugar changes, cardiovascular risk, pregnancy or breastfeeding status, and long-term exposure
Most patients start with every-other-night application for the first 1 to 2 weeks to minimize irritation from tretinoin, then increase to nightly use as tolerated
Starting at 0.5mg instead of 0.25mg is often fine, especially if you were tolerating moderate doses of your previous compound without issues
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