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However, systematic reviews and randomised controlled trials supporting these claims are notably absent from peer-reviewed literature

He has experienced nausea, headaches and hot flushes, but injects most nights before bed, sometimes double and triple dosing to get the desired result

[8] Early small-scale research suggested it may stimulate lipolysis (the breakdown of fat) and inhibit lipogenesis (fat storage), with preliminary data indicating it may not significantly affect blood glucose or insulin-like growth factor-1 (IGF-1) levels

Therefore, this review presents the triangle relationship of obesity, DM as well as cancer development and elucidates the treatment of overweight-associated T2DM with semaglutide, focusing on the question of whether the development of these conditions can be combated or if any severe side effects should be considered of this therapy