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A landmark review published in Biomolecules documenting GHK-Cus regulatory effects on over 4,000 human genes, including significant upregulation of collagen synthesis, anti-inflammatory pathways, and stem cell mobilization established the molecular basis for its clinical use

CJC-1295 is a GHRH analog and raises the basal GH level (trough), while Ipamorelin as a ghrelin-receptor mimetic triggers an additional, clean GH pulse