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There is a linear relationship between weight loss achieved in the diet-induced obesity preclinical model and weight loss achieved in clinical trials in various obese populations
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The subpopulation of adults with type 2 diabetes who participated in this sub-study had an overall baseline LFC of 15.7%
GLP-1 receptors are present in key brain regions involved in appetite regulation, including: The hypothalamus, which governs hunger and satiety signals The nucleus tractus solitarius in the brainstem, which processes signals from the gut Reward centres such as the ventral tegmental area and nucleus accumbens By activating these receptors, GLP-1 medications may reduce the rewarding properties of food and diminish food-related thoughts
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