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The Food and Drug Administration (FDA) has approved the following atypical antipsychotics: (* indicates the pharmacokinetics will be discussed in the next section) Aripiprazole (marketed as Abilify)* Asenapine Maleate (marketed as Saphris) Clozapine (marketed as Clozaril)* Risperidone (marketed as Risperdal)* Quetiapine (marketed as Seroquel)* Olanzapine (marketed as Zyprexa) Olanzapine/Fluoxetine (marketed as Symbyax) Iloperidone (marketed as Fanapt) Lurasidone (marketed as Latuda) Paliperidone (marketed as Invega) Ziprasidone (marketed as Geodon) Second-generation antipsychotics are approved for the treatment of the following: Mechanism of Action of Second-Generation Antipsychotics: Serotonin-Dopamine Antagonists (SDA) Typical antipsychotics act almost exclusively as blockers of dopamine-2 (D2) receptors
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Novo Nordisk (NVO): In 2023, Novo Nordisk announced the results from its SELECT trial that showed that semaglutide was associated with a 20% decreased risk of major adverse cardiac events comprised of cardiovascular death, nonfatal myocardial infarction (MI), and stroke compared with placebo in patients with overweight or obesity and established CVD but without diabetes
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