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For example, because STEP 1 trial eligibility criteria was used to identify NHANES participants, there may have been differences between the current study participants and STEP 1 participants, and therefore the weight loss and cardiovascular risk factor changes observed in STEP 1 may not be entirely translatable to our NHANES sample, Wong and colleagues wrote

Additionally, neurotrophic factors such as IGF-1 and BDNF are critical targets for facilitating slower rates of structural and functional decline in the brain with advancing ageas both promote neurogenesis (Park and Poo, 2013