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doi:10.1186/bcr3346 Takada, K., Melnikov, V

This slow titration approach significantly reduces the severity and duration of nausea compared to starting at higher doses

Structurally, these channel blockers are positioned within the GluK2 ion channel pore, located intracellular to the closed M3 helix bundle-crossing gate

Those who are lower on the obese BMI range - a BMI between 30 and 34.9kg/m2 - could also be offered the drug if they have a weight-related health condition