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Novo Nordisk is awaiting an FDA decision for their fixed-dose combination of the amylin receptor agonist, cagrilintide, and the GLP-1, semaglutide
Many patients do well long-term at 5 to 10 mg tirzepatide or 1.0 to 1.7 mg semaglutide
Can you give me examples of how this works
This was first suggested for the GLP-1R agonists exendin-4 and liraglutide when it was shown that the suppression of food intake that they cause upon systemic administration is prevented or attenuated when the GLP-1R antagonist exendin-9 is centrally administered in rats [7] and when central GLP-1Rs are deleted in mice [8]
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