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Across the same three decades that a hormone from a slow-moving reptile became the most-prescribed weight-loss drug in history, tens of millions of Americans have picked up a syringe pen that traces its molecular ancestry to a creature that eats three meals a year.

[PubMed ID: 22268031]

This modulation occurs by regulating the spinal dorsal horn microglial pathway through GLP-1R activation, leading to alterations in spinal excitatory synaptic transmission under neuropathic pain conditions 13,14,15,16,17,18

Corpas FJ, Barroso JB, del Ro LA (2001) Peroxisomes as a source of reactive oxygen species and nitric oxide signal molecules in plant cells