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The combination limited and variable BBB transport plus rapid plasma degradation means peripherally administered DSIP delivers a brief and structurally heterogeneous exposure to the central nervous system, complicating dose-response interpretation in any whole-animal experiment
The total frequency and grade of pathologic lesions were compared between genotypes using a chi-square test
The changes are rather inconsistent but trend toward correlation with disease activity and relapse risk (Tremlett et al., 2016)
Samples were washed for the final three times with 1 ml of PBS-B before analysis or sorting
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