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Taken together, these studies revealed two important principles: (1) that engineering of human IgG1 for improved binding towards FcRn impairs the pH dependency of its interaction with mouse FcRn, causing increased binding also at pH 7.4 and (2) that increased affinity of the IgG Fc:FcRn interaction at pH 7.4 results in a shortened, not prolonged serum persistence of IgG1 Fc fragments [100]

Freezing permanently damages the peptide structure and renders the medication ineffective

Keiner et al., 2017)

While its not clear if this risk applies to humans, its something that needs to be considered, especially if you have a history of thyroid issues