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ACLS Figure 4
Piperlongumine Piperlongumine (PL) is an alkaloid isolated from Piper species, commonly used in traditional medicine in particular in Asia and Latin America that in recent years has been extensively studied because of its anti-cancer potential, being able to inhibit proliferation in several cancer cell lines 107
Research suggests it participates in detoxification, peroxide reduction, and redox signaling by serving as a cofactor for glutathione-dependent enzymes
Lastly, we confirmed that cells surviving 5FU treatment do not increase mtDNA content to compensate for overwhelming mtDNA release (Extended Data Fig
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