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A diet and exercise program along with Semaglutide injection is used to control blood sugar levels in adults with type 2 diabetes (a condition in which insulin is not used normally and blood sugar cannot be controlled) when other medications were not effective in controlling blood sugar levels
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Still, that effect did not replicate at scale in the larger, longer Phase IIb study designed to confirm it which is the standard reason a compounds development gets discontinued rather than a sign the compound is unsafe
When external GLP-1 analogs are withdrawn, endogenous secretion may not sustain the same metabolic efficiency, often resulting in rebound appetite and weight regain
