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It acts as a selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme expressed in multiple tissues including adipose tissue and the liver that plays a role in cellular energy metabolism and fat storage
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As a supplement, it is thought to be healthier than folic acid
Although control FT282 cells were not sensitized to cisplatin by the suppression of KG, we did find that supplementation of KG modestly increased cisplatin IC 50 (Extended Data Fig
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