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View COA Research reference Overview Semaglutide is a long-acting 31-residue GLP-1 receptor analogue with a C18 fatty-diacid modification at Lys26 that extends its plasma half-life relative to native GLP-1

The level of pancreatic cholesterol in the T2DM and T2DM + sham group was markedly higher than the NC group, while compared to the T2DM + sham group, pancreatic cholesterol level dramatically decreased in T2DM + RYGB and T2DM + EX-4 groups (Figure 6J)

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