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Description

Oncogene 32 , 514 (2013)

Vitamin C is involved in the metabolism of tyrosine, carbohydrates, norepinephrine, histamine, and phenylalanine

Therefore, metformin can achieve glucose-lowering effects via the gut-liver axis and the gut-liver-brain axis, but the first site of metformin action is still the gut, so the gastrointestinal tract remains the main target of metformin action