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Compounds can leave behind metabolites or biological traces detectable for a longer period
Schertz, K
For a weekly injection schedule where vials remain in use for 4-10 weeks, stability matters significantly
In the first approach, a series of 4-chloro-6,7,8-trimethoxyquinazoline ( 29 ) derivatives were synthesized and coupled with a variety of amines, which indicated that 7,8-dimethoxy functionalization on the quinazoline ring enhanced PDE1B inhibition, while the presence of a third 6-methoxy group was neither beneficial nor detrimental
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