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Dual GLP-1/GIP agonists, such as tirzepatide, primarily enhance glycemic control and insulin sensitivity through synergistic incretin and -cell effects, producing the most pronounced HbA1c reductions among all classes
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When appetite drops naturally, adherence to caloric deficits becomes significantly easier compared to traditional weight loss approaches
Clinical best practice recommends tapering off gradually over four to eight weeks if discontinuation is medically necessary, rather than stopping cold turkey
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