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Larsson, L
This is the theoretical basis for endogenously supplied gamma-glutamylcysteines ability to raise GSH levels, as being the product of the GCL enzyme, it can be taken up by cells intact, where it feeds directly into glutathione synthase to be converted to glutathione, effectively bypassing the dysfunctional GCL
Specifically, rodent studies showed an increased incidence of thyroid C-cell tumours (medullary thyroid carcinoma) when exposed to GLP-1 receptor agonists at doses significantly higher than those used therapeutically in humans
Acting as an autocrine or paracrine hormone, FGF21 appears both to induce pathways that restore protein homeostasis, for example by enhancing TFEB-dependent lysosomal biogenesis to enable turnover of damaged proteins (154, 155)
