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While weight loss is a well-documented side effect of topiramate observed consistently in clinical trials this does not make it a weight loss medication

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Side effect rates at 12mg are meaningfully higher than at 8mg: Nausea: 43.2% of participants (vs 38.1% at 9mg) Diarrhea: 33.1% (vs 34.7% at 9mg) Constipation: 25.0% (vs 21.8% at 9mg) Vomiting: 20.9% (vs 20.4% at 9mg) The decision between 8mg, 10mg, and 12mg as a maintenance dose should be made based on individual response

Monomethoxy polyethylene glycol (PEG, 5 kDa) was obtained from Sigma-Aldrich and dried under vacuum prior to use