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Nevertheless, our findings in erythrocytes and previously published in SCD cardiac tissues 46 support that, in addition to inflammation suppression 23 and fetal globin induction 31,63,64 , DMF displays anti-oxidative and ferroptosis stress effects to alleviate SCD clinical severity, and therefore, might be pursued as a new treatment option
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Apr 3 2020;21(7)doi:10.3390/ijms21072484 Apolinario-Hagen J, Druge M, Fritsche L
M1 macrophages are pro-inflammatory, releasing cytokines that drive tissue destruction
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